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Tolfemax

Non-steroidal Anti-inflammatory

Tolfenamic acid (N- (2-methyl-3-chlorophenyl) anthranilic acid) is a non-steroidal anti-inflammatory drug (DAINE), extremely potent, which belongs to the family of fenamates such as meclofenamic acid.

  • Description

Description

Non-steroidal anti-inflammatory. Injectable solution

Composition:

Composition: Each mL contains:

Tolfénámico acid …………… 80 mg

Excipients …………. c.s.p. … 1 mL

Generalities: Tolfenamic acid (N- (2-methyl-3-chlorophenyl) anthranilic acid) is a non-steroidal anti-inflammatory drug (DAINE), extremely powerful, which belongs to the family of fenamates such as meclofenamic acid. It has proven to be very effective against many diseases in ruminants (cattle, sheep and South American camelids) and pigs: mastitis, respiratory disorders, MMA syndrome (mastitis, metritis, agalactia), arthritis, onfalectomy (navel cutting) among others. Tolfenámico acid exerts an anti-inflammatory, analgesic, antitoxic and antipyretic action. Due to its extraordinary power and its use, TOLFEMAX. 8% is perfectly adapted to the constraints of modern breeding. Pharmacodynamics – Mechanism of Action The anti-inflammatory activity of Tolfenamic acid is similar to that of other DAINEs; that is, it is based on the inhibition of the Cycloxygenases, but additionally has a direct antagonistic action on the prostaglandin and thromboxane receptors, causing a reduction in the synthesis of both substances; main mediators of inflammatory processes.

As an anti-inflammatory: It acts on the inflamed tissue at peripheral level by blocking the synthesis and decreasing the activity of prostaglandins and thromboxanes. It competes with prostaglandins for specific receptors in the cell membrane, interferes with the chemotaxis of leukocytes and the enzymatic release of lysosomes.

As an analgesic: It inhibits the generation of nociceptive nervous impulse at the peripheral level, raising the painful threshold.

As antipyretic: Produces peripheral vasodilation and increases heat loss.

Pharmacokinetics – Why have a Long Action? Tolfenamic acid undergoes an extensive enterohepatic recirculation, resulting in an extraordinarily prolonged concentration in the plasma for much longer.

An intramuscular injection (2 mg / kg: 2.5 mL / 100 kg) makes it effective for at least the next 48 hours after its application. For particular acute infections, intravenous administration is preferred, which has a much more powerful effect. For this reason, tolfenamic acid is the only authorized DAINE with an action of 48 hours.

The application can be repeated at 24 hour intervals (2 mg / kg: 2.5 mL / 100 kg) or administered as a single injection (4 mg / kg: 5 mL / 100 kg).

In cattle and ruminants, their half-life is much longer than other DAINEs commonly used in veterinary medicine. This makes its effect much longer:

AVERAGE LIFE TIME 12 hours 8 hours 1-3 hours TOLFEMAX 8% The average life of Tolfenámico acid in the organism varies from 3 to 5 hours in pigs and 8 to 15 hours in bovines. Tolfenamic acid is distributed in the body in high concentration in the plasma, digestive tract, liver, lung and kidney. However its concentration in the brain is low. Tolfenamic acid and its metabolites do not cross the placental barrier. The distribution of the Tolfenámico acid includes the extracellular fluids, in which concentrations similar to those of the plasma are obtained in both the peripheral tissues inflamed and healthy. It also appears in active form in the milk associated mainly with the curd. In bovines and pigs, Tolfenamic acid is mostly eliminated by faeces (30%) and urine (70%). In pigs, rapid absorption is manifested, after application of 2 mg / kg of live weight intramuscularly, obtaining a maximum plasma concentration (Cmax) of 2.3 ug in approximately 1 hour. The volume of the distribution is approximately 1.3 l / kg in pigs. It is extensively linked to plasma albumin (> 97%).

Species of destination – Tolfemax Therapeutic Indications 8%, can be used in cattle, sheep, South American camelids and porcine Equines and canines. Tolfemax 8% is a potent tetravalent agent: anti-inflammatory, antipyretic, antitoxic and analgesic. It is indicated in: Bovines, sheep, camelids: Treatment of acute bovine mastitis, associated with an antibacterial therapy. Tolfenamic acid is the only DAINE approved to treat mastitis with a single injection. Treatment of bacterial respiratory diseases associated with acute inflammations, associated with antibiotic therapy. In the treatment of any pathology that involves fever, inflammation and / or pain.

Swine: Treatment of metritis syndrome, agalactia mastitis (MMA) in sows associated with antibacterial therapy. Treatment of bacterial respiratory diseases associated with acute inflammations, associated with antibiotic therapy. In the treatment of any pathology that involves fever, inflammation and / or pain and in all cases that require anti-inflammatory, analgesic and / or antipyretic therapy. Dosage and Administration: Bovine, Sheep and South American Camelids: Tolfenamic acid is the only nonsteroidal anti-inflammatory drug authorized with a 48-hour action. It is regularly administered at a rate of 1 mL / 40 kg (2 mg / kg). In cases of mastitis and respiratory infections: A single dose of 1 mL / 40 kg live weight (2 mg / kg) intramuscularly or slowly intravenously. The dose will be effective for 48 hours. In case the infectious process continues, a second dose may be necessary after 48 hours. If the intravenous route is preferred (in particular cases of very acute infections), a single dose of 1 mL / 20 kg (4 mg / kg) or a treatment for 2 consecutive days should be applied at the dose of 1 mL / 40 kg (2 mg / kg).

Swine: A single dose of 1 mL / 40 kg of live weight by intramuscular deep in the neck muscles. When a large number of animals are being treated, the use of interchangeable needles is recommended. Contraindications TOLFEMAX. 8% is contraindicated in cases of heart or liver disease and in case of bleeding digestive ulcers. In case of evident hypersensitivity stop the use of the product.

Precautions In pigs apply only the intramuscular route. If applied to animals under 6 weeks of age, additional precautions should be taken in their dosage. Do not exceed the established dose or the duration of treatment. Comply aseptic precautions when administering the product. Do not administer more than 10 mL per inoculation point.

A swelling and swelling may occur at the site of application; which disappears without any treatment

Do not administer concurrently or within 24 hours with other non-steroidal anti-inflammatory drugs as some DAINEs may be highly linked to plasma proteins and compete with other drugs also linked; which can lead to toxic effects. Tolfemax 8% can be used during lactation. It can be used during pregnancy, however, like all products, it is recommended that these animals be administered under the observation of the Veterinarian. In case the product comes into contact with the skin or eyes of the manipulator, wash immediately with plenty of water.

Do not administer concurrently or within 24 hours with other non-steroidal anti-inflammatory drugs as some DAINEs may be highly linked to plasma proteins and compete with other drugs also linked; which can lead to toxic effects. Tolfemax 8% can be used during lactation. It can be used during pregnancy, however, like all products, it is recommended that these animals be administered under the observation of the Veterinarian. In case the product comes into contact with the skin or eyes of the manipulator, wash immediately with plenty of water.

Adverse Effects In isolated cases, a transient inflammatory reaction may occur at the injection site, which disappears without any treatment.

Withdrawal period Tolfenamic acid has been tested in dairy cattle with a particularly short suppression time (0 to 1 milking after the last administration)

Bovine, ovine and South American camelids: Meat: 3 days. Milk: During the treatment. Swine: Meat: 3 days

Horses: It is effective in any pathology that occurs with fever, inflammation and / or pain (anti-inflammatory, antitoxic, analgesic and / or antipyretic). Also used for the treatment of arthritis and other inflammatory disorders, whether acute or chronic, involving the skeletal muscle system. It has been used in laminitis treatments, with varying degrees of success.

Canines: It is indicated for the treatment of acute or chronic pain and / or inflammation in dogs.

Felines: Indicated for acute pain / inflammation in cats.

Target species: Equines, canines and felines.

Do not administer to equines whose meat is destined for human consumption.

Dosage, mode and method of administration

Horses: 2.5 ml / 100 Kg w / v (equivalent to 2 mg of Tolfenamic Acid for each kg of live weight). Via: Deep intramuscular (IM)

Canines:

For acute pain: 0.5 ml / 10 kg (equivalent to 4 mg of Tolfenamic Acid per kg). Via: Intramuscular or subcutaneous (IM / SC), for 3 to 5 days.

For chronic pain: 0.5 ml / 10 kg (equivalent to 4 mg of Tolfenamic Acid per kg). Via: Intramuscular or subcutaneous (IM / SC), for 3 to 5 days per week

Felines:

Indicated for acute pain / inflammation in cats.

For acute pain: 0.5 ml / 10 kg (equivalent to 4 mg of Tolfenamic Acid per kg). Via: Intramuscular or subcutaneous (IM / SC), for 3 to 5 days.

Interval between doses: Daily dose.

Treatment duration:

Horses: 2 to 3 days.

Canines: For acute pain: for 3 to 5 days.

For chronic pain: for 3 to 5 days per week.

Felines: For acute pain: for 3 to 5 days.

In all cases, the duration of the treatment is at the discretion of the acting veterinarian.